MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity

Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to target Mecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception. We confirmed MeCP2 upregulation in DRG following nerv...

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Autores principales: Manners, Melissa T., Tian, Yuzhen, Zhou, Zhaolan, Ajit, Seena K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571540/
https://www.ncbi.nlm.nih.gov/pubmed/26448907
http://dx.doi.org/10.1016/j.fob.2015.08.010
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author Manners, Melissa T.
Tian, Yuzhen
Zhou, Zhaolan
Ajit, Seena K.
author_facet Manners, Melissa T.
Tian, Yuzhen
Zhou, Zhaolan
Ajit, Seena K.
author_sort Manners, Melissa T.
collection PubMed
description Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to target Mecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception. We confirmed MeCP2 upregulation in DRG following nerve injury and repression of MeCP2 by miRNAs in vitro. MeCP2 regulates brain-derived neurotrophic factor (BDNF) and downregulation of MeCP2 by microRNAs decreased Bdnf in vitro. MeCP2 T158A mice exhibited reduced mechanical sensitivity and Mecp2-null and MeCP2 T158A mice have decreased Bdnf in DRG. MeCP2-mediated regulation of Bdnf in the DRG could contribute to altered pain sensitivity.
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spelling pubmed-45715402015-10-07 MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity Manners, Melissa T. Tian, Yuzhen Zhou, Zhaolan Ajit, Seena K. FEBS Open Bio Research article Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to target Mecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception. We confirmed MeCP2 upregulation in DRG following nerve injury and repression of MeCP2 by miRNAs in vitro. MeCP2 regulates brain-derived neurotrophic factor (BDNF) and downregulation of MeCP2 by microRNAs decreased Bdnf in vitro. MeCP2 T158A mice exhibited reduced mechanical sensitivity and Mecp2-null and MeCP2 T158A mice have decreased Bdnf in DRG. MeCP2-mediated regulation of Bdnf in the DRG could contribute to altered pain sensitivity. Elsevier 2015-08-31 /pmc/articles/PMC4571540/ /pubmed/26448907 http://dx.doi.org/10.1016/j.fob.2015.08.010 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research article
Manners, Melissa T.
Tian, Yuzhen
Zhou, Zhaolan
Ajit, Seena K.
MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
title MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
title_full MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
title_fullStr MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
title_full_unstemmed MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
title_short MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity
title_sort micrornas downregulated in neuropathic pain regulate mecp2 and bdnf related to pain sensitivity
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571540/
https://www.ncbi.nlm.nih.gov/pubmed/26448907
http://dx.doi.org/10.1016/j.fob.2015.08.010
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