The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

SLC30A8 encodes a zinc transporter ZnT8 largely restricted to pancreatic islet β- and α-cells, and responsible for zinc accumulation into secretory granules. Although common SLC30A8 variants, believed to reduce ZnT8 activity, increase type 2 diabetes risk in humans, rare inactivating mutations are p...

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Detalles Bibliográficos
Autores principales: Solomou, Antonia, Meur, Gargi, Bellomo, Elisa, Hodson, David J., Tomas, Alejandra, Migrenne Li, Stéphanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571871/
https://www.ncbi.nlm.nih.gov/pubmed/26178371
http://dx.doi.org/10.1074/jbc.M115.645291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571871/
https://www.ncbi.nlm.nih.gov/pubmed/26178371
http://dx.doi.org/10.1074/jbc.M115.645291

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