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A weighting approach for judging the effect of patient strata on high-dimensional risk prediction signatures

BACKGROUND: High-dimensional molecular measurements, e.g. gene expression data, can be linked to clinical time-to-event endpoints by Cox regression models and regularized estimation approaches, such as componentwise boosting, and can incorporate a large number of covariates as well as provide variab...

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Detalles Bibliográficos
Autores principales: Weyer, Veronika, Binder, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572441/
https://www.ncbi.nlm.nih.gov/pubmed/26374641
http://dx.doi.org/10.1186/s12859-015-0716-8