A CYP21A2 based whole-cell system in Escherichia coli for the biotechnological production of premedrol

BACKGROUND: Synthetic glucocorticoids like methylprednisolone (medrol) are of high pharmaceutical interest and represent powerful drugs due to their anti-inflammatory and immunosuppressive effects. Since the chemical hydroxylation of carbon atom 21, a crucial step in the synthesis of the medrol prec...

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Detalles Bibliográficos
Autores principales: Brixius-Anderko, Simone, Schiffer, Lina, Hannemann, Frank, Janocha, Bernd, Bernhardt, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572648/
https://www.ncbi.nlm.nih.gov/pubmed/26374204
http://dx.doi.org/10.1186/s12934-015-0333-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572648/
https://www.ncbi.nlm.nih.gov/pubmed/26374204
http://dx.doi.org/10.1186/s12934-015-0333-2

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