Cargando…

Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer

Glucocorticoids (GCs) have been widely used as coadjuvants in the treatment of solid tumours, but GC treatment may be associated with poor pharmacotherapeutic response or prognosis. The genomic action of GC in these tumours is largely unknown. Here we find that dexamethasone (Dex, a synthetic GC)-re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zhong, Lan, Xun, Wu, Dayong, Sunkel, Benjamin, Ye, Zhenqing, Huang, Jiaoti, Liu, Zhihua, Clinton, Steven K., Jin, Victor X., Wang, Qianben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573460/ https://www.ncbi.nlm.nih.gov/pubmed/26374485 http://dx.doi.org/10.1038/ncomms9323

Ejemplares similares

Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors
por: Ye, Zhenqing, et al.
Publicado: (2014)

Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1
por: Ye, Zhenqing, et al.
Publicado: (2016)

Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer
por: Wu, Dayong, et al.
Publicado: (2014)

Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range
por: Hankey, William, et al.
Publicado: (2020)

Phosphorylated MED1 links transcription recycling and cancer growth
por: Chen, Zhong, et al.
Publicado: (2022)

Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence
por: Sunkel, Benjamin, et al.
Publicado: (2016)

Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence
por: Sunkel, Benjamin, et al.
Publicado: (2017)

Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages
por: Lan, Xun, et al.
Publicado: (2012)

Differential Glucocorticoid-Dependent Regulation and Function of the ERRFI1 Gene in Triple-Negative Breast Cancer
por: Mojica, Chromewell Agustin R, et al.
Publicado: (2020)

Molecular determinants for enzalutamide-induced transcription in prostate cancer
por: Yuan, Fuwen, et al.
Publicado: (2019)

PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer
por: Noureddine, Lara Malik, et al.
Publicado: (2023)

4543 Glucocorticoid Receptors are essential effectors of TGFβ signaling in Triple Negative Breast Cancer
por: Kerkvliet, Carlos Jesus Perez, et al.
Publicado: (2020)

SUN-LB135 Estrogen Receptor Beta Inhibits NFkB Signaling to Inhibit Triple Negative Breast Cancer
por: Aspros, Kirsten, et al.
Publicado: (2020)

Glucocorticoid receptor overexpression slightly shifts microRNA expression patterns in triple-negative breast cancer
por: Buschmann, Dominik, et al.
Publicado: (2018)

Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity
por: Chu, Quyen D., et al.
Publicado: (2012)

Small Peptide Ligands for Targeting EGFR in Triple Negative Breast Cancer Cells
por: Hossein-Nejad-Ariani, Hanieh, et al.
Publicado: (2019)

Positive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer
por: Zeng, Yan, et al.
Publicado: (2019)

Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple-Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha
por: Sperlich, Julia, et al.
Publicado: (2018)

Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands
por: SenGupta, Shuvasree, et al.
Publicado: (2021)

Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling
por: Chen, Zhong, et al.
Publicado: (2021)

Pro-Asthmatic Cytokines Regulate Unliganded and Ligand-Dependent Glucocorticoid Receptor Signaling in Airway Smooth Muscle
por: Hu, Aihua, et al.
Publicado: (2013)

Targeting of prostate-specific membrane antigen for radio-ligand therapy of triple-negative breast cancer
por: Morgenroth, Agnieszka, et al.
Publicado: (2019)

Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer
por: Elkashif, Ahmed, et al.
Publicado: (2020)

Overexpression of Programmed Death-Ligand 1 Receptor mRNA as an Independent Negative Prognostic Factor for Triple Negative Breast Cancer
por: Purwanto, Ibnu, et al.
Publicado: (2020)

Transcriptome Meta-Analysis of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy
por: Zhang, Wei, et al.
Publicado: (2023)

SUN-008 The Glucocorticoid Receptor Is Essential For TGFβ and p38 MAPK Mediated Cancer Phenotypes in Triple Negative Breast Cancer
por: Perez Kerkvliet, Carlos, et al.
Publicado: (2019)

Impact of Glucocorticoid Receptor Density on Ligand-Independent Dimerization, Cooperative Ligand-Binding and Basal Priming of Transactivation: A Cell Culture Model
por: Robertson, Steven, et al.
Publicado: (2013)

Efficacy of Sequential Capecitabine on Adjuvant Chemotherapy of Triple-Negative Breast Cancer
por: Xi, Xun, et al.
Publicado: (2022)

Repeated Negative Biopsies in Isolated High-Grade Cystic Duct Dysplasia with Progression to Adenocarcinoma
por: Sunkel-Laing, Benjamin, et al.
Publicado: (2014)

Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1
por: Hankey, William, et al.
Publicado: (2018)

Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma
por: Jin, Linfang, et al.
Publicado: (2020)

The Iron-Inflammation Axis in Early-Stage Triple-Negative Breast Cancer
por: Duan, Fangfang, et al.
Publicado: (2022)

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
por: Swanner, Jessica, et al.
Publicado: (2015)

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer
por: Gao, Yujing, et al.
Publicado: (2022)

Wnt ligand–dependent activation of the negative feedback regulator Nkd1
por: Larraguibel, Jahdiel, et al.
Publicado: (2015)

Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics
por: Marek, Carylyn J, et al.
Publicado: (2009)

Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?
por: Van Moortel, Laura, et al.
Publicado: (2020)

An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer
por: Ryall, Karen A, et al.
Publicado: (2015)

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells
por: Wang, Yubao, et al.
Publicado: (2018)

Co-dependency for MET and FGFR1 in basal triple-negative breast cancers
por: Sung, Vanessa Y. C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lv78brh9d56h344carv00795rc