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Why the Central Dogma: on the nature of the great biological exclusion principle
ABSTRACT: The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573691/ https://www.ncbi.nlm.nih.gov/pubmed/26377089 http://dx.doi.org/10.1186/s13062-015-0084-3 |
Sumario: | ABSTRACT: The Central Dogma of molecular biology posits that transfer of information from proteins back to nucleic acids does not occur in biological systems. I argue that the impossibility of reverse translation is indeed a major, physical exclusion principle that emerges due to the transition from the digital information carriers, nucleic acids, to analog information carriers, proteins, which involves irreversible suppression of the digital information. REVIEWERS: This article was reviewed by Itai Yanai, Martin Lercher and Frank Eisenhaber. |
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