Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, and the key question remains as to how differentiation in tumor cells can...

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Detalles Bibliográficos
Autores principales: Váraljai, Renáta, Islam, Abul B.M.M.K., Beshiri, Michael L., Rehman, Jalees, Lopez-Bigas, Nuria, Benevolenskaya, Elizaveta V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573855/
https://www.ncbi.nlm.nih.gov/pubmed/26314709
http://dx.doi.org/10.1101/gad.264036.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573855/
https://www.ncbi.nlm.nih.gov/pubmed/26314709
http://dx.doi.org/10.1101/gad.264036.115

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