A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

Certain missense mutations in optineurin/OPTN and amplification of TBK1 are associated with normal tension glaucoma. A glaucoma-associated variant of OPTN, M98K, induces autophagic degradation of transferrin receptor (TFRC) and death in retinal cells. Here, we have explored the role of Tbk1 in M98K-...

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Detalles Bibliográficos
Autores principales: Sirohi, Kapil, Kumari, Asha, Radha, Vegesna, Swarup, Ghanshyam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574030/
https://www.ncbi.nlm.nih.gov/pubmed/26376340
http://dx.doi.org/10.1371/journal.pone.0138289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574030/
https://www.ncbi.nlm.nih.gov/pubmed/26376340
http://dx.doi.org/10.1371/journal.pone.0138289

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