Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV

HIV-1 is already known to have an extremely fast mutation rate, but a new study shows it to be more than two orders of magnitude higher than previously believed, and that this is largely due to host cytidine deaminases. Read the Research Article.

Detalles Bibliográficos
Autor principal: Robinson, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574152/
https://www.ncbi.nlm.nih.gov/pubmed/26375682
http://dx.doi.org/10.1371/journal.pbio.1002252
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author Robinson, Richard
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description HIV-1 is already known to have an extremely fast mutation rate, but a new study shows it to be more than two orders of magnitude higher than previously believed, and that this is largely due to host cytidine deaminases. Read the Research Article.
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spelling pubmed-45741522015-09-18 Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV Robinson, Richard PLoS Biol Synopsis HIV-1 is already known to have an extremely fast mutation rate, but a new study shows it to be more than two orders of magnitude higher than previously believed, and that this is largely due to host cytidine deaminases. Read the Research Article. Public Library of Science 2015-09-16 /pmc/articles/PMC4574152/ /pubmed/26375682 http://dx.doi.org/10.1371/journal.pbio.1002252 Text en © 2015 Richard Robinson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Synopsis
Robinson, Richard
Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV
title Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV
title_full Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV
title_fullStr Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV
title_full_unstemmed Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV
title_short Cellular Defense Enzyme Drives Exceptionally High Rate of Mutation in HIV
title_sort cellular defense enzyme drives exceptionally high rate of mutation in hiv
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574152/
https://www.ncbi.nlm.nih.gov/pubmed/26375682
http://dx.doi.org/10.1371/journal.pbio.1002252
work_keys_str_mv AT robinsonrichard cellulardefenseenzymedrivesexceptionallyhighrateofmutationinhiv

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