The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages

The HIV-1 envelope protein gp120 is both the target of neutralizing antibodies and a major focus of vaccine efforts; however how it is delivered to B cells to elicit an antibody response is unknown. Here, we show that following local gp120 injection lymph node (LN) SIGN-R1(+) sinus macrophages locat...

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Detalles Bibliográficos
Autores principales: Park, Chung, Arthos, James, Cicala, Claudia, Kehrl, John H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574315/
https://www.ncbi.nlm.nih.gov/pubmed/26258881
http://dx.doi.org/10.7554/eLife.06467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574315/
https://www.ncbi.nlm.nih.gov/pubmed/26258881
http://dx.doi.org/10.7554/eLife.06467

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