Cargando…

Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression

We recently identified Smads1, 5 and 8 as muscle biomarkers in human ALS. In the ALS mouse, these markers are elevated and track disease progression. Smads are signal transducers and become activated upon receptor engagement of ligands from the TGF-β superfamily. Here, we sought to characterize liga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Si, Ying, Kim, Soojin, Cui, Xiangqin, Zheng, Lei, Oh, Shin J., Anderson, Tina, AlSharabati, Mohammad, Kazamel, Mohamed, Volpicelli-Daley, Laura, Bamman, Marcas M., Yu, Shaohua, King, Peter H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574401/ https://www.ncbi.nlm.nih.gov/pubmed/26375954 http://dx.doi.org/10.1371/journal.pone.0138425

Ejemplares similares

Smads as muscle biomarkers in amyotrophic lateral sclerosis
por: Si, Ying, et al.
Publicado: (2014)

Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study
por: Lee, Ikjae, et al.
Publicado: (2021)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133b
por: Lopez, Michael A., et al.
Publicado: (2022)

Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
por: Stolfi, Carmine, et al.
Publicado: (2020)

Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines.
por: Damstrup, L., et al.
Publicado: (1993)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

Increased transforming growth factor beta (TGF-β) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury
por: Kilari, Sreenivasulu, et al.
Publicado: (2018)

Participation of the SMAD2/3 signalling pathway in the down regulation of megalin/LRP2 by transforming growth factor beta (TGF-ß1)
por: Cabezas, Felipe, et al.
Publicado: (2019)

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1
Publicado: (1990)

TGF‐β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners
por: Zou, Li‐Li, et al.
Publicado: (2021)

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro
por: Tang, Li-xia, et al.
Publicado: (2012)

TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model
por: Li, Guo-Cai, et al.
Publicado: (2012)

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro
Publicado: (1987)

SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma
por: Kaur, Gagandeep, et al.
Publicado: (2018)

Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma.
por: Krasagakis, K., et al.
Publicado: (1998)

Growth differentiation factor 11 inhibits adipogenic differentiation by activating TGF‐beta/Smad signalling pathway
por: Luo, Hongke, et al.
Publicado: (2019)

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2019)

Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway
por: Wang, Xue-Ming, et al.
Publicado: (2020)

Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens
por: Saneyasu, Takaoki, et al.
Publicado: (2022)

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta)
Publicado: (1991)

The role of transforming growth factor-beta (TGF-beta) during ovarian follicular development in sheep
por: Juengel, Jennifer L, et al.
Publicado: (2004)

Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
por: Papoutsoglou, Panagiotis, et al.
Publicado: (2019)

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia
Publicado: (1991)

Meeting Synopsis: Advances in Skeletal Muscle Biology in Health and Disease (Gainesville, Florida, February 22nd to 24th 2012) – Day 1: “Cell Signaling Mechanisms Mediating Muscle Atrophy and Hypertrophy” and “muscle Force, Calcium Handling, and Stress Response”
por: Judge, Andrew R., et al.
Publicado: (2012)

Meeting Synopsis: Advances in Skeletal Muscle Biology in Health and Disease (Gainesville, Florida, February 22nd to 24th 2012) – Day 2: “Muscle Diseases and Regeneration” and “Clinical/Translational Research”
por: Judge, Andrew R., et al.
Publicado: (2012)

Corrigendum: Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2020)

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats
por: Meng, Ke, et al.
Publicado: (2021)

SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway
por: Zhang, Jinhang, et al.
Publicado: (2018)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-β)/Smad4 Signalling Pathway
por: Yuan, Xuemin, et al.
Publicado: (2018)

Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis
por: Zhang, Liting, et al.
Publicado: (2019)

Circular RNA HECTD1 knockdown inhibits transforming growth factor-beta/ small mothers against decapentaplegic (TGF-β/Smad) signaling to reduce hypertrophic scar fibrosis
por: Ge, Xiaojing, et al.
Publicado: (2022)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

A 50 kdyne contusion spinal cord injury with or without the drug SS‐31 was not associated with major changes in muscle mass or gene expression 14 d after injury in young male mice
por: Graham, Zachary A., et al.
Publicado: (2021)

SS‐31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice
por: Graham, Zachary A., et al.
Publicado: (2022)

Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
por: Wyller, Vegard Bruun, et al.
Publicado: (2017)

A transforming growth factor beta 2 (TGF-beta 2)-like immunosuppressive factor in amniotic fluid and localization of TGF-beta 2 mRNA in the pregnant uterus
Publicado: (1990)

ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway
por: Du, Tiancong, et al.
Publicado: (2022)

Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats
por: Meng, Ke, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7kjmpr7sssvtut0unbpeu6mbdf