TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production

BACKGROUND: Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a key regulator of signal cascades of TNF-α receptor and TLR4, and can induce NF-κB activation for preventing cell apoptosis and eliciting inflammation response. RESULTS: TAK1 inhibitor (TAKI) can decrease the cell viabili...

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Detalles Bibliográficos
Autores principales: Wang, Jang-Shiun, Wu, Dean, Huang, Duen-Yi, Lin, Wan-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574455/
https://www.ncbi.nlm.nih.gov/pubmed/26381601
http://dx.doi.org/10.1186/s12929-015-0182-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574455/
https://www.ncbi.nlm.nih.gov/pubmed/26381601
http://dx.doi.org/10.1186/s12929-015-0182-7

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