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Activation and reactivation of the RNA polymerase II trigger loop for intrinsic RNA cleavage and catalysis

In addition to RNA synthesis, multisubunit RNA polymerases (msRNAPs) support enzymatic reactions such as intrinsic transcript cleavage. msRNAP active sites from different species appear to exhibit differential intrinsic transcript cleavage efficiency and have likely evolved to allow fine-tuning of t...

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Detalles Bibliográficos
Autores principales: Čabart, Pavel, Jin, Huiyan, Li, Liangtao, Kaplan, Craig D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574878/
https://www.ncbi.nlm.nih.gov/pubmed/25764335
http://dx.doi.org/10.4161/trns.28869