Exendin-4 Prevents Vascular Smooth Muscle Cell Proliferation and Migration by Angiotensin II via the Inhibition of ERK1/2 and JNK Signaling Pathways

Angiotensin II (Ang II) is a main pathophysiological culprit peptide for hypertension and atherosclerosis by causing vascular smooth muscle cell (VSMC) proliferation and migration. Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, is currently used for the treatment of type-2 diabetes,...

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Detalles Bibliográficos
Autores principales: Nagayama, Kosuke, Kyotani, Yoji, Zhao, Jing, Ito, Satoyasu, Ozawa, Kentaro, Bolstad, Francesco A., Yoshizumi, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574935/
https://www.ncbi.nlm.nih.gov/pubmed/26379274
http://dx.doi.org/10.1371/journal.pone.0137960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574935/
https://www.ncbi.nlm.nih.gov/pubmed/26379274
http://dx.doi.org/10.1371/journal.pone.0137960

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