Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund’s Adjuvant Models of Pain

While genetic evidence shows that the Nav1.7 voltage-gated sodium ion channel is a key regulator of pain, it is unclear exactly how Nav1.7 governs neuronal firing and what biophysical, physiological, and distribution properties of a pharmacological Nav1.7 inhibitor are required to produce analgesia....

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Detalles Bibliográficos
Autores principales: Matson, David J., Hamamoto, Darryl T., Bregman, Howard, Cooke, Melanie, DiMauro, Erin F., Huang, Liyue, Johnson, Danielle, Li, Xingwen, McDermott, Jeff, Morgan, Carrie, Wilenkin, Ben, Malmberg, Annika B., McDonough, Stefan I., Simone, Donald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575030/
https://www.ncbi.nlm.nih.gov/pubmed/26379236
http://dx.doi.org/10.1371/journal.pone.0138140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575030/
https://www.ncbi.nlm.nih.gov/pubmed/26379236
http://dx.doi.org/10.1371/journal.pone.0138140

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