mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated in cell and animal models. mTOR overactivation in alveolar epithelial cells (AECs) was achieved in the conditional and inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1 (fx/+) (STT). Doxycycline cau...

Descripción completa

Detalles Bibliográficos
Autores principales: Gui, Yao-Song, Wang, Lianmei, Tian, Xinlun, Li, Xue, Ma, Aiping, Zhou, Weixun, Zeng, Ni, Zhang, Ji, Cai, Baiqiang, Zhang, Hongbing, Chen, Jing-Yu, Xu, Kai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575195/
https://www.ncbi.nlm.nih.gov/pubmed/26382847
http://dx.doi.org/10.1371/journal.pone.0138625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575195/
https://www.ncbi.nlm.nih.gov/pubmed/26382847
http://dx.doi.org/10.1371/journal.pone.0138625

Ejemplares similares