A biomimetic approach for enhancing the in vivo half-life of peptides

The tremendous therapeutic potential of peptides has not yet been realized, mainly due to their short in vivo half-life. While conjugation to macromolecules has been a mainstay approach for enhancing the half-life of proteins, the steric hindrance of macromolecules often harms the binding of peptide...

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Detalles Bibliográficos
Autores principales: Penchala, Sravan C, Miller, Mark R, Pal, Arindom, Dong, Jin, Madadi, Nikhil R., Xie, Jinghang, Joo, Hyun, Tsai, Jerry, Batoon, Patrick, Samoshin, Vyacheslav, Franz, Andreas, Cox, Trever, Miles, Jesse, Chan, William K, Park, Miki S, Alhamadsheh, Mamoun M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575266/
https://www.ncbi.nlm.nih.gov/pubmed/26344696
http://dx.doi.org/10.1038/nchembio.1907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575266/
https://www.ncbi.nlm.nih.gov/pubmed/26344696
http://dx.doi.org/10.1038/nchembio.1907

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