Human Calprotectin Is an Iron-Sequestering Host-Defense Protein

Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis...

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Detalles Bibliográficos
Autores principales: Nakashige, Toshiki G., Zhang, Bo, Krebs, Carsten, Nolan, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575267/
https://www.ncbi.nlm.nih.gov/pubmed/26302479
http://dx.doi.org/10.1038/nchembio.1891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575267/
https://www.ncbi.nlm.nih.gov/pubmed/26302479
http://dx.doi.org/10.1038/nchembio.1891

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