Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells

BACKGROUND: Neuroblastoma (NB) is one of the most common childhood malignancies. Currently, high risk NB carries a poor outcome and significant treatment related toxicities and, thus has been a focus for new therapeutics research in pediatric oncology. In this study, we evaluated the effects of the...

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Detalles Bibliográficos
Autores principales: Singh, Anjali, Ruan, Yibing, Tippett, Tanya, Narendran, Aru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575431/
https://www.ncbi.nlm.nih.gov/pubmed/26384788
http://dx.doi.org/10.1186/s13046-015-0222-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575431/
https://www.ncbi.nlm.nih.gov/pubmed/26384788
http://dx.doi.org/10.1186/s13046-015-0222-x

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