The Involvement of Mutual Inhibition of ERK and mTOR in PLCγ1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes

The issue of whether ERK activation determines matrix synthesis or degradation in osteoarthritis (OA) pathogenesis currently remains controversial. Our previous study shows that PLCγ1 and mTOR are involved in the matrix metabolism of OA cartilage. Investigating the interplays of PLCγ1, mTOR and ERK...

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Detalles Bibliográficos
Autores principales: Liu, Zejun, Cai, Heguo, Zheng, Xinpeng, Zhang, Bing, Xia, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576213/
https://www.ncbi.nlm.nih.gov/pubmed/26247939
http://dx.doi.org/10.3390/ijms160817857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576213/
https://www.ncbi.nlm.nih.gov/pubmed/26247939
http://dx.doi.org/10.3390/ijms160817857

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