Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions

Cell-cycle fluctuations drive significant transcriptomic heterogeneity in murine hematopoietic stem cells. Additionally, deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice. Please see related Research article: http://www.genomebiology.com/20...

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Detalles Bibliográficos
Autores principales: Powers, Ashley N, Satija, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576375/
https://www.ncbi.nlm.nih.gov/pubmed/26390863
http://dx.doi.org/10.1186/s13059-015-0778-y
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author Powers, Ashley N
Satija, Rahul
author_facet Powers, Ashley N
Satija, Rahul
author_sort Powers, Ashley N
collection PubMed
description Cell-cycle fluctuations drive significant transcriptomic heterogeneity in murine hematopoietic stem cells. Additionally, deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice. Please see related Research article: http://www.genomebiology.com/2015/16/1/178
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spelling pubmed-45763752015-09-22 Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions Powers, Ashley N Satija, Rahul Genome Biol Research Highlight Cell-cycle fluctuations drive significant transcriptomic heterogeneity in murine hematopoietic stem cells. Additionally, deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice. Please see related Research article: http://www.genomebiology.com/2015/16/1/178 BioMed Central 2015-09-21 2015 /pmc/articles/PMC4576375/ /pubmed/26390863 http://dx.doi.org/10.1186/s13059-015-0778-y Text en © Powers and Satija. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Powers, Ashley N
Satija, Rahul
Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions
title Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions
title_full Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions
title_fullStr Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions
title_full_unstemmed Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions
title_short Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions
title_sort single-cell analysis reveals key roles for bcl11a in regulating stem cell fate decisions
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576375/
https://www.ncbi.nlm.nih.gov/pubmed/26390863
http://dx.doi.org/10.1186/s13059-015-0778-y
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AT satijarahul singlecellanalysisrevealskeyrolesforbcl11ainregulatingstemcellfatedecisions

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