Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

BACKGROUND: Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogene...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsang, Jason C. H., Yu, Yong, Burke, Shannon, Buettner, Florian, Wang, Cui, Kolodziejczyk, Aleksandra A., Teichmann, Sarah A., Lu, Liming, Liu, Pentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576406/
https://www.ncbi.nlm.nih.gov/pubmed/26387834
http://dx.doi.org/10.1186/s13059-015-0739-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576406/
https://www.ncbi.nlm.nih.gov/pubmed/26387834
http://dx.doi.org/10.1186/s13059-015-0739-5

Ejemplares similares