Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

BACKGROUND: Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogene...

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Detalles Bibliográficos
Autores principales: Tsang, Jason C. H., Yu, Yong, Burke, Shannon, Buettner, Florian, Wang, Cui, Kolodziejczyk, Aleksandra A., Teichmann, Sarah A., Lu, Liming, Liu, Pentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576406/
https://www.ncbi.nlm.nih.gov/pubmed/26387834
http://dx.doi.org/10.1186/s13059-015-0739-5

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