Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes i...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaolai, Sun, Lirong, Bastos de Oliveira, Francisco, Qi, Xiaoyang, Brown, William J., Smolka, Marcus B., Sun, Ying, Hu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576858/
https://www.ncbi.nlm.nih.gov/pubmed/26370502
http://dx.doi.org/10.1083/jcb.201502029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576858/
https://www.ncbi.nlm.nih.gov/pubmed/26370502
http://dx.doi.org/10.1083/jcb.201502029

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