Short Communication: HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120's V3 Crown with CCR5 Extracellular Loop 1

The CCR5 coreceptor amino terminus and extracellular (ECL) loops 1 and 2 have been implicated in HIV-1 infections, with species differences in these regions inhibiting zoonoses. Interactions of gp120 with CD4 and CCR5 reduce constraints on metastable envelope subunit gp41, enabling gp41 conformation...

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Detalles Bibliográficos
Autores principales: Platt, Emily J., Durnin, James P., Kabat, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576943/
https://www.ncbi.nlm.nih.gov/pubmed/26114311
http://dx.doi.org/10.1089/aid.2015.0131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576943/
https://www.ncbi.nlm.nih.gov/pubmed/26114311
http://dx.doi.org/10.1089/aid.2015.0131

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