Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation

The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in their 3’ or 5’ untranslated region (UTR). Multiple lines of experimental evidence suggest that this process plays a key role in c...

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Detalles Bibliográficos
Autores principales: Wang, Zhonghua, Bhattacharya, Akash, Ivanov, Dmitri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577092/
https://www.ncbi.nlm.nih.gov/pubmed/26390015
http://dx.doi.org/10.1371/journal.pone.0138780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577092/
https://www.ncbi.nlm.nih.gov/pubmed/26390015
http://dx.doi.org/10.1371/journal.pone.0138780

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