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Phosphorylation of Izumo1 and its role in male infertility

Izumo1 is a testis-specific gene product, whose function is essential for sperm-egg fusion. Throughout its lifespan, Izumo1 is posttranslationally modified, being both N-linked glycosylated on its extracellular domain and phosphorylated on the intracellular C-terminal tail. Within the caput regions...

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Autores principales: Young, Samantha AM, Aitken, John, Baker, Mark A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577576/
https://www.ncbi.nlm.nih.gov/pubmed/25994654
http://dx.doi.org/10.4103/1008-682X.156119
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author Young, Samantha AM
Aitken, John
Baker, Mark A
author_facet Young, Samantha AM
Aitken, John
Baker, Mark A
author_sort Young, Samantha AM
collection PubMed
description Izumo1 is a testis-specific gene product, whose function is essential for sperm-egg fusion. Throughout its lifespan, Izumo1 is posttranslationally modified, being both N-linked glycosylated on its extracellular domain and phosphorylated on the intracellular C-terminal tail. Within the caput regions of the rat epididymis, two phosphorylation events have been documented. However, as sperm pass through the epididymis, this cytoplasmic portion of Izumo1 has been shown to contain up to seven phosphorylation sites. Remarkably, in the rat, in correlation with these events, Izumo1 undergoes sub-cellular re-location, moving from the head/tail regions of the spermatozoa, to a predominantly equatorial segment location once they have reached the caudal end of the epididymis.
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spelling pubmed-45775762015-09-23 Phosphorylation of Izumo1 and its role in male infertility Young, Samantha AM Aitken, John Baker, Mark A Asian J Androl Invited Review Izumo1 is a testis-specific gene product, whose function is essential for sperm-egg fusion. Throughout its lifespan, Izumo1 is posttranslationally modified, being both N-linked glycosylated on its extracellular domain and phosphorylated on the intracellular C-terminal tail. Within the caput regions of the rat epididymis, two phosphorylation events have been documented. However, as sperm pass through the epididymis, this cytoplasmic portion of Izumo1 has been shown to contain up to seven phosphorylation sites. Remarkably, in the rat, in correlation with these events, Izumo1 undergoes sub-cellular re-location, moving from the head/tail regions of the spermatozoa, to a predominantly equatorial segment location once they have reached the caudal end of the epididymis. Medknow Publications & Media Pvt Ltd 2015 2015-05-18 /pmc/articles/PMC4577576/ /pubmed/25994654 http://dx.doi.org/10.4103/1008-682X.156119 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms
spellingShingle Invited Review
Young, Samantha AM
Aitken, John
Baker, Mark A
Phosphorylation of Izumo1 and its role in male infertility
title Phosphorylation of Izumo1 and its role in male infertility
title_full Phosphorylation of Izumo1 and its role in male infertility
title_fullStr Phosphorylation of Izumo1 and its role in male infertility
title_full_unstemmed Phosphorylation of Izumo1 and its role in male infertility
title_short Phosphorylation of Izumo1 and its role in male infertility
title_sort phosphorylation of izumo1 and its role in male infertility
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577576/
https://www.ncbi.nlm.nih.gov/pubmed/25994654
http://dx.doi.org/10.4103/1008-682X.156119
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