Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1

Eukaryotic mRNA contains a 3′ poly(A) tail, which plays important roles in the regulation of mRNA stability and translation. Well-characterized enzymes involved in the shortening of the poly(A) tail include the multi-subunit Ccr4-Not deadenylase, which contains the Caf1 (Pop2) and Ccr4 catalytic com...

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Detalles Bibliográficos
Autores principales: Jadhav, Gopal P., Kaur, Ishwinder, Maryati, Maryati, Airhihen, Blessing, Fischer, Peter M., Winkler, G. Sebastiaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577731/
https://www.ncbi.nlm.nih.gov/pubmed/26299350
http://dx.doi.org/10.1016/j.bmcl.2015.07.095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577731/
https://www.ncbi.nlm.nih.gov/pubmed/26299350
http://dx.doi.org/10.1016/j.bmcl.2015.07.095

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