Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

[Image: see text] There is a need for new molecular-guided contrast agents to enhance surgical procedures such as tumor resection that require a high degree of precision. Cysteine cathepsins are highly up-regulated in a wide variety of cancers, both in tumor cells and in the tumor-supporting cells o...

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Detalles Bibliográficos
Autores principales: Ofori, Leslie O., Withana, Nimali P., Prestwood, Tyler R., Verdoes, Martijn, Brady, Jennifer J., Winslow, Monte M., Sorger, Jonathan, Bogyo, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577961/
https://www.ncbi.nlm.nih.gov/pubmed/26039341
http://dx.doi.org/10.1021/acschembio.5b00205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577961/
https://www.ncbi.nlm.nih.gov/pubmed/26039341
http://dx.doi.org/10.1021/acschembio.5b00205

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