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Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

High resolution proteomics increasingly reveals that most native ion channels are assembled in macromolecular complexes. However, whether different partners have additive or cooperative functional effects, or whether some combinations of proteins may preclude assembly of others are largely unexplore...

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Detalles Bibliográficos
Autores principales: Gonzalez-Perez, Vivian, Xia, Xiao-Ming, Lingle, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578311/
https://www.ncbi.nlm.nih.gov/pubmed/26388335
http://dx.doi.org/10.1038/ncomms9341