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Statistical significance approximation in local trend analysis of high-throughput time-series data using the theory of Markov chains

BACKGROUND: Local trend (i.e. shape) analysis of time series data reveals co-changing patterns in dynamics of biological systems. However, slow permutation procedures to evaluate the statistical significance of local trend scores have limited its applications to high-throughput time series data anal...

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Detalles Bibliográficos
Autores principales: Xia, Li C., Ai, Dongmei, Cram, Jacob A., Liang, Xiaoyi, Fuhrman, Jed A., Sun, Fengzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578688/
https://www.ncbi.nlm.nih.gov/pubmed/26390921
http://dx.doi.org/10.1186/s12859-015-0732-8