Response to sunitinib of a gastrointestinal stromal tumor with a rare exon 12 PDGFRA mutation

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are commonly driven by activating mutations in either KIT or PDGFRA. Importantly, different mutations within these two genes can lead to very different levels of sensitivity or resistance to kinase inhibitor therapy. Due to rarity, sensitivity or r...

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Detalles Bibliográficos
Autores principales: Brohl, Andrew S., Demicco, Elizabeth G., Mourtzikos, Karen, Maki, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578851/
https://www.ncbi.nlm.nih.gov/pubmed/26396737
http://dx.doi.org/10.1186/s13569-015-0036-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578851/
https://www.ncbi.nlm.nih.gov/pubmed/26396737
http://dx.doi.org/10.1186/s13569-015-0036-9

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