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Response to sunitinib of a gastrointestinal stromal tumor with a rare exon 12 PDGFRA mutation
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are commonly driven by activating mutations in either KIT or PDGFRA. Importantly, different mutations within these two genes can lead to very different levels of sensitivity or resistance to kinase inhibitor therapy. Due to rarity, sensitivity or r...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578851/ https://www.ncbi.nlm.nih.gov/pubmed/26396737 http://dx.doi.org/10.1186/s13569-015-0036-9 |