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microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma

This study demonstrates the effects of miRNA-10b on medulloblastoma proliferation through transcriptional induction of the anti-apoptotic protein BCL2. Using a cancer specific miRNA-array, high expression of miRNA-10b in medulloblastoma cell lines compared to a normal cerebellar control was shown, a...

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Detalles Bibliográficos
Autores principales: Pal, Rekha, Greene, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579065/
https://www.ncbi.nlm.nih.gov/pubmed/26394044
http://dx.doi.org/10.1371/journal.pone.0137845