Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin

Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS a...

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Detalles Bibliográficos
Autores principales: Bertoncello, Nádia, Moreira, Roseli Peres, Arita, Danielle Yuri, Aragão, Danielle S., Watanabe, Ingrid Kazue Mizuno, Dantas, Patricia S., Santos, Ralmony, Mattar-Rosa, Rodolfo, Yokota, Rodrigo, Cunha, Tatiana Sousa, Casarini, Dulce Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579315/
https://www.ncbi.nlm.nih.gov/pubmed/26442284
http://dx.doi.org/10.1155/2015/674047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579315/
https://www.ncbi.nlm.nih.gov/pubmed/26442284
http://dx.doi.org/10.1155/2015/674047

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