Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation prot...

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Detalles Bibliográficos
Autores principales: Ryu, Jae Kyu, Petersen, Mark A., Murray, Sara G., Baeten, Kim M., Meyer-Franke, Anke, Chan, Justin P., Vagena, Eirini, Bedard, Catherine, Machado, Michael R., Coronado, Pamela E. Rios, Prod'homme, Thomas, Charo, Israel F., Lassmann, Hans, Degen, Jay L., Zamvil, Scott S., Akassoglou, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579523/
https://www.ncbi.nlm.nih.gov/pubmed/26353940
http://dx.doi.org/10.1038/ncomms9164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579523/
https://www.ncbi.nlm.nih.gov/pubmed/26353940
http://dx.doi.org/10.1038/ncomms9164

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