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Higher -Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function
BRCC36 is a Zn(2+) dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition. The MPN(+) domain protein BRCC36 associates with pseudo-DUB MPN(−) prot...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579573/ https://www.ncbi.nlm.nih.gov/pubmed/26344097 http://dx.doi.org/10.1016/j.molcel.2015.07.028 |