Higher -Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function

BRCC36 is a Zn(2+) dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition. The MPN(+) domain protein BRCC36 associates with pseudo-DUB MPN(−) prot...

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Detalles Bibliográficos
Autores principales: Zeqiraj, Elton, Tian, Lei, Piggott, Christopher A., Pillon, Monica C., Duffy, Nicole M., Ceccarelli, Derek F., Keszei, Alexander F. A., Lorenzen, Kristina, Kurinov, Igor, Orlicky, Stephen, Gish, Gerald D., Heck, Albert J.R., Guarné, Alba, Greenberg, Roger A., Sicheri, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579573/
https://www.ncbi.nlm.nih.gov/pubmed/26344097
http://dx.doi.org/10.1016/j.molcel.2015.07.028

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