dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

Central nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to the difficulty of delivering drugs into the CNS. Here we identify a cell-permeable peptide, dNP2, which...

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Detalles Bibliográficos
Autores principales: Lim, Sangho, Kim, Won-Ju, Kim, Yeon-Ho, Lee, Sohee, Koo, Ja-Hyun, Lee, Jung-Ah, Yoon, Heeseok, Kim, Do-Hyun, Park, Hong-Jai, Kim, Hye-Mi, Lee, Hong-Gyun, Yun Kim, Ji, Lee, Jae-Ung, Hun Shin, Jae, Kyun Kim, Lark, Doh, Junsang, Kim, Hongtae, Lee, Sang-Kyou, Bothwell, Alfred L. M., Suh, Minah, Choi, Je-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579786/
https://www.ncbi.nlm.nih.gov/pubmed/26372309
http://dx.doi.org/10.1038/ncomms9244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579786/
https://www.ncbi.nlm.nih.gov/pubmed/26372309
http://dx.doi.org/10.1038/ncomms9244

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