Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length

Almost 400 genes affect yeast telomere length, including Est1, which is critical for recruitment and activation of telomerase. Here we use mass spectrometry to identify novel telomerase regulators by their co-purification with the telomerase holoenzyme. In addition to all known subunits, over 100 pr...

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Detalles Bibliográficos
Autores principales: Lin, Kah-Wai, McDonald, Karin R., Guise, Amanda J., Chan, Angela, Cristea, Ileana M., Zakian, Virginia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579843/
https://www.ncbi.nlm.nih.gov/pubmed/26365526
http://dx.doi.org/10.1038/ncomms9290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579843/
https://www.ncbi.nlm.nih.gov/pubmed/26365526
http://dx.doi.org/10.1038/ncomms9290

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