Mitochondrial dysfunction in aging: Much progress but many unresolved questions

The free radical theory of aging is almost 60 years old. As mitochondria are the principle source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. In recent years, however, much work has questioned the importanc...

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Detalles Bibliográficos
Autores principales: Payne, Brendan A.I., Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580208/
https://www.ncbi.nlm.nih.gov/pubmed/26050973
http://dx.doi.org/10.1016/j.bbabio.2015.05.022
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author Payne, Brendan A.I.
Chinnery, Patrick F.
author_facet Payne, Brendan A.I.
Chinnery, Patrick F.
author_sort Payne, Brendan A.I.
collection PubMed
description The free radical theory of aging is almost 60 years old. As mitochondria are the principle source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. In recent years, however, much work has questioned the importance of mitochondrial ROS in driving aging. Conversely new evidence points to other facets of mitochondrial dysfunction which may nevertheless suggest the mitochondrion retains a critical role at the center of a complex web of processes leading to cellular and organismal aging.
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spelling pubmed-45802082015-11-01 Mitochondrial dysfunction in aging: Much progress but many unresolved questions Payne, Brendan A.I. Chinnery, Patrick F. Biochim Biophys Acta Article The free radical theory of aging is almost 60 years old. As mitochondria are the principle source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. In recent years, however, much work has questioned the importance of mitochondrial ROS in driving aging. Conversely new evidence points to other facets of mitochondrial dysfunction which may nevertheless suggest the mitochondrion retains a critical role at the center of a complex web of processes leading to cellular and organismal aging. Elsevier Pub. Co 2015-11 /pmc/articles/PMC4580208/ /pubmed/26050973 http://dx.doi.org/10.1016/j.bbabio.2015.05.022 Text en Crown Copyright © 2015 Published by Elsevier B.V. All rights reserved. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Payne, Brendan A.I.
Chinnery, Patrick F.
Mitochondrial dysfunction in aging: Much progress but many unresolved questions
title Mitochondrial dysfunction in aging: Much progress but many unresolved questions
title_full Mitochondrial dysfunction in aging: Much progress but many unresolved questions
title_fullStr Mitochondrial dysfunction in aging: Much progress but many unresolved questions
title_full_unstemmed Mitochondrial dysfunction in aging: Much progress but many unresolved questions
title_short Mitochondrial dysfunction in aging: Much progress but many unresolved questions
title_sort mitochondrial dysfunction in aging: much progress but many unresolved questions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580208/
https://www.ncbi.nlm.nih.gov/pubmed/26050973
http://dx.doi.org/10.1016/j.bbabio.2015.05.022
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