Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease

BACKGROUND: Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents. Although deep brain stimulation (DBS) of a highly heterogeneous brain structure, the pedunculopontine nucleus (PPN...

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Detalles Bibliográficos
Autores principales: Pienaar, Ilse S., Gartside, Sarah E., Sharma, Puneet, De Paola, Vincenzo, Gretenkord, Sabine, Withers, Dominic, Elson, Joanna L., Dexter, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580350/
https://www.ncbi.nlm.nih.gov/pubmed/26394842
http://dx.doi.org/10.1186/s13024-015-0044-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580350/
https://www.ncbi.nlm.nih.gov/pubmed/26394842
http://dx.doi.org/10.1186/s13024-015-0044-5

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