Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A

To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction of CYP450 were performed: a) In vitro use of the rat fresh hepatocytes model; b) In vivo ‘cocktail’ of CYP450 probe model; c) Pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Li, Xin, Li, Ying, Gong, Wei, Yang, Mei Yan, Yang, Yang, Li, Zhi Ping, Wang, Yu Li, Zhang, Zhen Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580629/
https://www.ncbi.nlm.nih.gov/pubmed/26397835
http://dx.doi.org/10.1371/journal.pone.0138875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580629/
https://www.ncbi.nlm.nih.gov/pubmed/26397835
http://dx.doi.org/10.1371/journal.pone.0138875

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