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Deciphering targeting rules of splicing modulator compounds: case of TG003

BACKGROUND: Recent advances in the development of small chemical compounds that can modulate RNA splicing brought excitement to the field of splicing-targeting therapy. Splicing-targeting therapy tries to ameliorate the disease by altering the exon combination of transcripts to reduce the undesired...

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Detalles Bibliográficos
Autores principales: Sakuma, Maki, Iida, Kei, Hagiwara, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580995/
https://www.ncbi.nlm.nih.gov/pubmed/26400733
http://dx.doi.org/10.1186/s12867-015-0044-6