UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib

Chronic myeloid leukemia (CML) cells express the active BCR-ABL1 protein, which has been targeted by imatinib in CML therapy, but resistance to this drug is an emerging problem. BCR-ABL1 induces endogenous oxidative stress promoting genomic instability and imatinib resistance. In the present work, w...

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Detalles Bibliográficos
Autores principales: Synowiec, Ewelina, Hoser, Grazyna, Wojcik, Katarzyna, Pawlowska, Elzbieta, Skorski, Tomasz, Błasiak, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581238/
https://www.ncbi.nlm.nih.gov/pubmed/26251899
http://dx.doi.org/10.3390/ijms160818111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581238/
https://www.ncbi.nlm.nih.gov/pubmed/26251899
http://dx.doi.org/10.3390/ijms160818111

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