Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

Aspartic proteases are a class of enzymes that play a causative role in numerous diseases such as malaria (plasmepsins), Alzheimer’s disease (β-secretase), fungal infections (secreted aspartic proteases), and hypertension (renin). We have chosen endothiapepsin as a model enzyme of this class of enzy...

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Detalles Bibliográficos
Autores principales: Hartman, Alwin M., Mondal, Milon, Radeva, Nedyalka, Klebe, Gerhard, Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581293/
https://www.ncbi.nlm.nih.gov/pubmed/26287174
http://dx.doi.org/10.3390/ijms160819184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581293/
https://www.ncbi.nlm.nih.gov/pubmed/26287174
http://dx.doi.org/10.3390/ijms160819184

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