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Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways

Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. We previously reported that CD44, a receptor for the extracellular matrix glycosaminoglycan hyalu...

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Detalles Bibliográficos
Autores principales: Ruppert, Shannon M., Falk, Ben A., Long, S. Alice, Bollyky, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581548/
https://www.ncbi.nlm.nih.gov/pubmed/26448755
http://dx.doi.org/10.1155/2015/614297