Cargando…

Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways

Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. We previously reported that CD44, a receptor for the extracellular matrix glycosaminoglycan hyalu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruppert, Shannon M., Falk, Ben A., Long, S. Alice, Bollyky, Paul L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581548/ https://www.ncbi.nlm.nih.gov/pubmed/26448755 http://dx.doi.org/10.1155/2015/614297

Ejemplares similares

Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan
Publicado: (1996)

Cell-in-cell structure mediates in-cell killing suppressed by CD44
por: Su, Yan, et al.
Publicado: (2022)

CD44 targets Wnt/β-catenin pathway to mediate the proliferation of K562 cells
por: Chang, Guoqiang, et al.
Publicado: (2013)

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4(+)CD25(+) Regulatory T-Cells of Type 1 Diabetic Subjects
por: Long, S. Alice, et al.
Publicado: (2010)

Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis
por: Pan, Meng, et al.
Publicado: (2021)

Interplay between Podoplanin, CD44s and CD44v in Squamous Carcinoma Cells
por: Montero-Montero, Lucía, et al.
Publicado: (2020)

Anticancer Analysis of CD44 Targeted Cyclosporine Loaded Thiolated Chitosan Nanoformulations for Sustained Release in Triple-Negative Breast Cancer
por: Abduh, Maisa Siddiq
Publicado: (2023)

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
por: Okamoto, Isamu, et al.
Publicado: (2001)

Downregulation of CD44 reduces doxorubicin resistance of CD44(+)CD24(−) breast cancer cells
por: Van Phuc, Pham, et al.
Publicado: (2011)

Novel CD44-downstream signaling pathways mediating breast tumor invasion
por: Ouhtit, Allal, et al.
Publicado: (2018)

CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling
por: Yuan, Shyng-Shiou F., et al.
Publicado: (2022)

A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth
por: Park, Jihyun, et al.
Publicado: (2016)

CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells
por: Liu, Zhiyong, et al.
Publicado: (2016)

PDGF Suppresses the Sulfation of CD44v and Potentiates CD44v-Mediated Binding of Colon Carcinoma Cells to Fibrin under Flow
por: Alves, Christina S., et al.
Publicado: (2012)

Cardiovascular Effects Mediated by HMMR and CD44
por: Jaskuła, Kinga, et al.
Publicado: (2021)

Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells
por: Al-Rekabi, Zeinab, et al.
Publicado: (2019)

Activated mouse astrocytes and T cells express similar CD44 variants. Role of CD44 in astrocyte/T cell binding
Publicado: (1993)

Effect of CD44 on differentiation of human amniotic mesenchymal stem cells into chondrocytes via Smad and ERK signaling pathways
por: Xu, Yan, et al.
Publicado: (2020)

ARPP-19 Mediates Herceptin Resistance via Regulation of CD44 in Gastric Cancer
por: Gao, Xiang, et al.
Publicado: (2020)

Chemokine CCL20 promotes the paclitaxel resistance of CD44(+)CD117(+) cells via the Notch1 signaling pathway in ovarian cancer
por: Chen, Min, et al.
Publicado: (2021)

CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway
por: Jijiwa, Mayumi, et al.
Publicado: (2011)

Cyclosporine A Induces Apoptotic and Autophagic Cell Death in Rat Pituitary GH3 Cells
por: Kim, Han Sung, et al.
Publicado: (2014)

Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NFκB-Mediated Chemokine Production
por: Olofsson, Berit, et al.
Publicado: (2014)

Cosmc Disruption-Mediated Aberrant O-glycosylation Suppresses Breast Cancer Cell Growth via Impairment of CD44
por: Du, Tan, et al.
Publicado: (2020)

CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin
por: Ouhtit, Allal, et al.
Publicado: (2020)

CD44(+) fibroblasts increases breast cancer cell survival and drug resistance via IGF2BP3‐CD44‐IGF2 signalling
por: Liu, Yonglei, et al.
Publicado: (2017)

Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44
por: Umemura, Naoki, et al.
Publicado: (2016)

Galectin-9 promotes natural killer cells activity via interaction with CD44
por: Rahmati, Amirhossein, et al.
Publicado: (2023)

NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death
por: Shemesh, Avishai, et al.
Publicado: (2018)

Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes
por: Assayag-Asherie, Nathalie, et al.
Publicado: (2015)

CD44: A Multifunctional Mediator of Cancer Progression
por: Hassn Mesrati, Malak, et al.
Publicado: (2021)

CD117(+)CD44(+) Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway
por: Wei, Yang, et al.
Publicado: (2017)

Ribosome biogenesis mediates antitumor activity of flavopiridol in CD44(+)/CD24(−) breast cancer stem cells
por: Erol, Ayse, et al.
Publicado: (2017)

Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions
por: Murakami, Tomoyuki, et al.
Publicado: (2018)

Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
por: Whelan, Kelly A., et al.
Publicado: (2017)

Ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction: A case report
por: Zhang, Chi, et al.
Publicado: (2017)

Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
por: Moon, Daeun, et al.
Publicado: (2019)

Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte "homing" receptor expressed by hemopoietic cells
Publicado: (1991)

CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression
por: Wang, Zhe, et al.
Publicado: (2018)

Epithelial and dendritic cells in the thymic medulla promote CD4(+)Foxp3(+) regulatory T cell development via the CD27–CD70 pathway
por: Coquet, Jonathan M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vdk6nf0k38sgntm62fstti5hub