Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO(3)-Induced DNA Damage

We have developed a kinetic model to investigate how DNA repair processes and scavengers of reactive oxygen species (ROS) can affect the dose-response shape of prooxidant induced DNA damage. We used as an example chemical KBrO(3) which is activated by glutathione and forms reactive intermediates tha...

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Detalles Bibliográficos
Autores principales: Spassova, Maria A., Miller, David J., Nikolov, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581570/
https://www.ncbi.nlm.nih.gov/pubmed/26448819
http://dx.doi.org/10.1155/2015/764375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581570/
https://www.ncbi.nlm.nih.gov/pubmed/26448819
http://dx.doi.org/10.1155/2015/764375

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