Cargando…
Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway
The in utero environment profoundly impacts childhood neurodevelopment and behaviour. A substantial proportion of pregnancies in Africa are at risk of malaria in pregnancy (MIP) however the impact of in utero exposure to MIP on fetal neurodevelopment is unknown. Complement activation, in particular...
Autores principales: | McDonald, Chloë R., Cahill, Lindsay S., Ho, Keith T., Yang, Jimmy, Kim, Hani, Silver, Karlee L., Ward, Peter A., Mount, Howard T., Liles, W. Conrad, Sled, John G., Kain, Kevin C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581732/ https://www.ncbi.nlm.nih.gov/pubmed/26402732 http://dx.doi.org/10.1371/journal.ppat.1005140 |
Ejemplares similares
-
PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria
por: Serghides, Lena, et al.
Publicado: (2014) -
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria
por: Patel, Samir N., et al.
Publicado: (2008) -
C5a Enhances Dysregulated Inflammatory and Angiogenic Responses to Malaria In Vitro: Potential Implications for Placental Malaria
por: Conroy, Andrea, et al.
Publicado: (2009) -
Impact of antiretroviral therapy intensification with C-C motif chemokine receptor 5 antagonist maraviroc on HIV-associated neurocognitive impairment
por: Shikuma, Cecilia M., et al.
Publicado: (2023) -
Antigen-driven C–C Chemokine-mediated HIV-1 Suppression by CD4(+) T Cells from Exposed Uninfected Individuals Expressing the Wild-type CCR-5 Allele
por: Furci, Lucinda, et al.
Publicado: (1997)